Suggestions for increased quality

• Training courses in quality control and statistics at basic academic level as well as advice in quality control at different levels.

• Peer reviewers should be informed in statistics and GLP.

• Definition and set up of relevant positive control for each model.

• Standardisation and clear guidelines for prevalidation and validation.

• Clear criteria for submission of new methods in the OECD process for acceptance.

• Clear timeline and increased transparency of the process of validation and submission for the OECD process for acceptance.