Test models included

Cytotoxicity

The Caco-2 model

Colony forming unit-granulocyte/

macrophage (CFU-GM) assays

Methods with commercial potential

Already used

commercially

Already used commercially

Yes

Endpoints

Acute toxicity

Subacute and subchronic

Toxicokinetics and metabolism

Expected field of application

Stage of development

Basic research on

mechanistic end points

Optimization method

Pre-validating

Expected regulatory acceptance

Yes

Expected interest from the market

All end users and manufacturers

The whole blood assay

LLC-PK1/TER model for nephrotoxicity

Different assays for testing neurotoxicity

Cytomic

Neural network

Yes

Yes

Yes

Ecotoxicology

Blood brain barrier

Nephrotoxicity

Hepatoxicity

Expected regulatory acceptance

Expected interest from the market